CD274 and neoplasm: Similarly, inhibition of LSD1 in triple-negative breast cancer(TNBC) by RNAi or HCI-2509 promoted the expression of PD-L1 by increasing its level of H3K4me2, resulting in a significant increase of TNBC immunogenicity, significantly inhibiting tumor growth and metastasis in combination with an anti-PD-1 antibody [169].