CD4 and systemic lupus erythematosus: Several previous studies [9–11] have also performed DNA methylation screening in CD4+T cells or peripheral blood mononuclear cells (PBMCs) from SLE patients and found several DMPs or genes unique to the LN population, such as cg10152499 (CHST12) and cg15065340 (TNK2) gene [9, 10].