A large number of studies have shown elevated cerebrospinal fluid (CSF) and plasma levels of isoprostanes and prostaglandins in AD [5, 10–16], but their relation with established Amyloid, Tau, Neurodegeneration (ATN biomarkers: amyloid-beta 42 [Aβ-42], phosphorylated-tau [p-tau], and total-tau [t-tau]) [17] is not yet studied during the prodromal phase of AD or linked to the progression from mild cognitive impairment (MCI) to AD dementia. This evidence concerns the gene MAPT and Alzheimer disease.