A large number of studies have shown elevated cerebrospinal fluid (CSF) and plasma levels of isoprostanes and prostaglandins in AD [5, 10–16], but their relation with established Amyloid, Tau, Neurodegeneration (ATN biomarkers: amyloid-beta 42 [Aβ-42], phosphorylated-tau [p-tau], and total-tau [t-tau]) [17] is not yet studied during the prodromal phase of AD or linked to the progression from mild cognitive impairment (MCI) to AD dementia. The gene discussed is MAPT; the disease is Cognitive impairment.