We validated the downregulation of the NE markers NEUROD1, ASCL1 and SYP, and increase of NOTCH2 and HES1, both involved in promoting low-NE differentiation in SCLC [10, 12], at the protein level after treatment with FHD-286 (Fig. 2G). The gene discussed is NOTCH2; the disease is small cell lung carcinoma.