ChIP-seq of SMARCA4 in NE-high SCLC PDXs revealed binding to regulatory elements of lineage TFs including ASCL1, NEUROD1, FOXA2 and INSM1 as well as to relevant genes implicated in axonogenesis, synapse formation, and neuropeptide signaling pathways. The gene discussed is SMARCA4; the disease is small cell lung carcinoma.