Induction of NOTCH signaling in SCLC-A can promote SCLC state shift through at least two complementary mechanisms: [1] suppression of ASCL1 and ASCL1 target gene expression, and [2] upregulation of REST, a transcription factor that inhibits transcription of a set of NE genes including many non-overlapping from those under ASCL1 control [12]. This evidence concerns the gene ASCL1 and small cell lung carcinoma.