CD40LG and Alzheimer disease: A comprehensive meta-analysis of 170 studies revealed significantly elevated blood concentrations of various proteins including hs-CRP, IL-6, soluble tumor necrosis factor receptors 1 and 2 (sTNFR1 and TNFR2), α1-antichymotrypsin (α1-ACT), IL-1β, and soluble CD40 ligand (sCD40L) in patients with AD compared to controls.