CNTN2 and adult T-cell leukemia/lymphoma: Hasegawa et al. [39] demonstrated experimentally that the short-term cultivation of autologous PBMCs generates the Tax protein, which can serve as a therapeutic vaccine that activates cytotoxic T lymphocytes in STLV-1-infected JMs with impaired cytotoxic T lymphocytes, as seen in patients with adult T-cell leukemia/lymphoma.