BDNF and type 2 diabetes mellitus: Among the DE-miRNAs identified in T2DM-CAD, we discovered hsa-miR-4505, hsa-miR-4717-3p, and hsa-miR-7850-5p to be essential regulators of signaling by neurotrophins, predominantly NGF, through TRK receptors, which are highly expressed in endothelial cells and VSMCs [61].