By the PPI network analysis, we extracted the top ten hub genes separately for up-regulated (PTEN, PRKCA, PKM, CD4, POLR2E, CALR, MAP2K7, SREBF1, U2AF2, SLC2A1) and down-regulated (ACTB, MYC, RHOA, CDK1, UBXN7, RPS16, CCT7, EEF2, SMAD2, GNAQ) miRNAs in T2DM-CAD. The gene discussed is SMAD2; the disease is coronary artery disorder.