The gene targets of the up-regulated miRNAs were significantly overrepresented in terms related to pathways in cancers, signal transduction, mainly calcium, epidermal growth factor receptor (EGFR) and nerve growth factor (NGF) signaling pathways, metabolism, calcium ion and protein binding, cell-cell communication, cell adhesion, and cell junction organization (Fig. 3A). The gene discussed is EGFR; the disease is cancer.