PRKCA and diabetes mellitus: Moreover, calcium-dependent and diacylglycerol-activated PKCα (PRKCA) under hyperglycemic settings has been found to promote ROS-producing enzymes and oxidative stress, the expression of endothelial adhesion molecules, pro-inflammatory cytokine production, and deteriorate nitric oxide-dependent vasodilation, indicating that it may be a mediator of the onset of diabetes-related atherosclerosis [70].