To elucidate the mechanism of action of miR-19a-3p in endothelial dysfunction, we used TargetScan (Release8.0, http://www.targetscan.org/) to identify the downstream target of miR-19a-3p and found a putative binding site in the 3’-UTR of JCAD mRNA to the seed sequence of miR-19a-3p, which is highly conserved across numerous species (Fig. 4A). Here, JCAD is linked to endothelial dysfunction.