SAA1 and AA amyloidosis: In a murine model of AA amyloidosis, subcutaneous administration of silver nitrate (AgNO3), coupled with an intravenous application of preformed SAA fibrils (known as Amyloid-Enhancing Factor or AEF), rapidly induces AA amyloidosis in spleen (Kisilevsky and Boudreau, 1983; Lundmark et al, 2013; Sponarova et al, 2013).