PSEN1 and early-onset autosomal dominant Alzheimer disease: Since SAA activates macrophages (Chen et al, 2020; Gaiser et al, 2021; Niemi et al, 2011), and Pycard+/− astrocytes of APP/PS1 transgenic mice overexpressing mutant amyloid β precursor protein and presenilin-1 (a mouse model of Alzheimer’s disease) show increased Aβ phagocytosis (Couturier et al, 2016), we investigated whether the presence or absence of ASC, in the context of SAA induction, influences the phagocytic activity of murine bone marrow-derived macrophages (BMDMs) in vitro (Appendix Fig. S7A,S7B).