The adapter protein ASC (Apoptosis-associated speck-like protein containing a caspase recruitment domain) plays an eminent role in the pathogenesis of Alzheimer’s disease (AD) (Dansokho and Heneka, 2018; Ising et al, 2019; Venegas et al, 2017). Here, PYCARD is linked to early-onset autosomal dominant Alzheimer disease.