Also, cryopyrin-associated periodic syndrome (CAPS) patients, owing to a genetic condition, have constitutively high NLRP3 and ASC inflammasome activation (Pastore et al, 2013; Scarpioni et al, 2016) and are at high risk of developing AA amyloidosis (Brunger et al, 2020). Here, PYCARD is linked to AA amyloidosis.