ASC was shown to co-localize with AA amyloid in kidney biopsies from patients with AA amyloidosis secondary to familial Mediterranean fever, where a gain-of-function mutation in the Pyrin gene activates ASC inflammasomes and leads to chronic overexpression of SAA (Balci-Peynircioglu et al, 2008). This evidence concerns the gene PYCARD and AA amyloidosis.