CD4 and neoplasm: Meanwhile, the release and accumulation of Ifng and Cxcl10 further remodeled the tumor microenvironment, by enhancing tumor-infiltrating immune cells (such as CD4+ and CD8 + T cells), and inducing a T cell-inflamed gene expression profile (contained Ifng-responsive genes such as Irf1, Gbp, Iigp1, Igtp).