While myeloid leukocyte migration, neutrophil chemotaxis, and neutrophil migration were enriched in significantly upregulated genes of the polarized pattern (Fig. 4B), which linked to tumor proliferation and inflammatory mediator synthesis12 and neutrophils recruited by chemotaxis may turn into tissue resident neutrophils associated with anti-PD-L1 treatment failure13. Here, CD274 is linked to neoplasm.