HAVCR2 and acute lymphoblastic leukemia: Moreover, the T-ALL cell lines presented two HAVCR2 expression patterns with high levels of TOX and TOX2: low HAVCR2 mRNA expression plus high TOX and TOX2 mRNA levels, such as in Jurkat, HPBALL, P12-ICHIKAWA, and MOLT3 cells, or high HAVCR2 mRNA expression plus high TOX and TOX2 mRNA levels, such as in HUT102 and LOUCY cells (Fig. 1B).