To further confirm the role of TIM3 and TOX2 nuclear translocation in T-ALL cells, we forced TIM3 expression, knocked out TOX or TOX2 expression, or inhibited TOX2 nuclear translocation using shLCOR-1 or HDAC3 inhibitor chidamide in Jurkat cells. The gene discussed is HAVCR2; the disease is acute lymphoblastic leukemia.