However, we determined that the distinct TIM3 expression in T-ALL cell line Jurkat and MOLT3, lymphoblastic cell line T2, and OKT3-stimulated normal T cells was induced by the nuclear-cytosol translocation of TOX2, and nuclear TOX and TOX2 formed a complex that suppressed HAVCR2 transcription by recruiting co-suppressor LCOR and acetylase HDAC3 (Sirt1). Here, HAVCR2 is linked to acute lymphoblastic leukemia.