In addition, TIM3 and caspase 1 expression were increased in tumor samples from Jurkat-TOXsg-tumor and Jurkat-TIM3-tumor related to Jurkat-sgControl -tumor, but caspase 3 levels were not changed in these three tumor tissues (Fig. 7E and Supplementary Fig. 5A–C). This evidence concerns the gene HAVCR2 and neoplasm.