Moreover, increased levels of NfL, Ptau181, Aβ40, Aβ42/40 and decreased Aβ40 were also found in AD patients compared with aMCI patients (p < 0.05), while there was no statistical difference (p > 0.05) in T-tau protein and Aβ42 between the two groups. This evidence concerns the gene MAPT and Alzheimer disease.