In blood from donors with psoriasis (n = 4), JNJ-77242113 inhibited IL-23–induced IFNγ production with a median IC50 value of 9 pM (range: 0.5–35 pM; Fig. 2D; Table 1), indicating an inhibitory potency similar to that observed in blood from healthy volunteers. The gene discussed is IL23A; the disease is psoriasis.