Additionally, ATF6’s role in promoting microbiome-dependent tumor formation through intestinal flora imbalance and innate immune responses [34], or facilitating prostate cancer progression via the ATF6α–PLA2G4A pathway affecting arachidonic acid metabolism [31], highlights its varied implications in cancer dynamics, albeit its limited reported involvement in angiogenesis, similar to PERK. This evidence concerns the gene PLA2G4A and Familial prostate cancer.