TMEM175 and early-onset autosomal dominant Alzheimer disease: Genetic correlations between PD, Alzheimer’s disease, and Lewy body dementia (LBD) have been investigated in the literature47,48 and a few loci have been reported to be shared between these diseases such as TMEM175, MAPT, KANSL1. We sought to identify potential overlaps between the 175 proteins in the top 1% module of the hypothesis-free network analysis and risk genes identified in Alzheimer’s Disease.