In age-related macular degeneration (Zhao et al. 2021) and retinitis pigmentosa (Yang et al. 2021), iron accumulation and decreased Glutathione Peroxidase 4/ Glutathione (GPX4/GSH) levels lead to iron death in retinitis pigmentosa and photoreceptor cells. Here, GPX4 is linked to age-related macular degeneration.