On multivariate survival analyses, tumor stage (HR 1.830, 95%CI 1.046 – 3.77), margin status (HR 1.501, 95%CI 1.210 – 4.063), Ki-67 > 10% (HR 2.125,95%CI 1.632 ~ 4.089) post-operative chemotherapy without mitotane (HR 1.620, 95%CI 1.133 – 7.125) as well as low FCV (HR 3.138, 95%CI 2.53 – 7.962) remained independent predictors of a shorter RFS (all P < 0.05; Table 3). Here, MKI67 is linked to neoplasm.