In addition, in T-ALL, the NUP214-ABL1 fusion gene is known to be an oncogene that leads to constitutive tyrosine kinase activity and activation of several downstream signaling pathways (e.g., the PI3K/AKT/mTOR and JAK/STAT pathways) that are crucial for cell cycle progression and survival, ultimately leading to the pathological proliferation of T cells (Simioni et al. 2016; Kleppe et al. 2011; Quintás-Cardama et al. 2008). The gene discussed is NUP214; the disease is acute lymphoblastic leukemia.