Similarly, overexpression of NUP37 activates PI3K/AKT signaling, promoting the proliferation, migration, and invasion of gastric cancer (GC) cells (Zhang et al. 2021a), and forms an immunosuppressive microenvironment in gliomas (He et al. 2022) (Fig. 2 and Table 1). Here, AKT1 is linked to gastric cancer.