POM121 and cancer: In various cancer types, including CRC (Wang et al. 2020), lung cancer (Guan et al. 2021; Zhang et al. 2020b), laryngocarcinoma (Zhao et al. 2020), PCa (Becker et al. 2022), GC (Kang et al. 2023), and oral SCC (Ma et al. 2019b), the oncoprotein POM121 is universally overexpressed and plays a role in modulating key signaling pathways.