The NUP358-ALK fusion occurs because of a rearrangement within chromosome (chr) 2q13, resulting in constitutive, ligand-independent autophosphorylation and activation of the receptor tyrosine kinase ALK, which promotes uncontrolled cell growth and leads to tumor formation (Ma et al. 2003; Mariño-Enríquez et al. 2011; Lee et al. 2017) (Fig. 3 and Table 2). The gene discussed is RANBP2; the disease is neoplasm.