In mammal, Nup358 has diverse functions involved in the regulation of nucleocytoplasmic transport, viral infection, and cancer progression (Jiang et al. 2022; Gloerich et al. 2011; Wang et al. 2018), notably resulting from the combination of the intrinsic properties of its protein domains (e.g., SUMO-interacting motifs) and the various subcellular localizations of Nup358 (e.g., NPCs and kinetochores) (Liu et al. 2020; Joseph et al. 2004; Forler et al. 2004; Cooper et al. 2005). Here, RANBP2 is linked to cancer.