CEBPA and hepatocellular carcinoma: In HCC, NUP358 directly promotes CCAAT/enhancer-binding protein alpha (CEBPα) SUMOylation and degradation, affecting the balance of the O-GlcNAcylation enzymes O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA), subsequently triggering more O-GlcNAcylation events for oncogenic proteins (Liu et al. 2021c).