HSF1 and ependymoma: Furthermore, TPR protects cells from RNA-mediated replication stress by regulating heat-shock transcription factor 1 (HSF1) mRNA trafficking, maintaining mTORC1 activity to phosphorylate Unc-51-like kinase 1 (ULK1), and preventing macroautophagy/autophagy induction in ependymoma (Kosar et al. 2021; Dewi et al. 2021).