Pathologically, TPR has been implicated in cancer through several types of abnormalities, including chromosomal translocations that generate fusion proteins with several receptor tyrosine kinases (Greco et al. 1997; Choi et al. 2014; Lee et al. 2021), regulation of nuclear translocation of RNAs (Kosar et al. 2021; Chen et al. 2021), and point mutations found in several types of cancer (Forbes et al. 2017; Moon et al. 2021); however, the underlying mechanism is unclear. This evidence concerns the gene NTRK1 and cancer.