RANBP2 and viral infectious disease: Specifically, individuals with missense mutations in the N-terminal region of NUP358 (mainly T585M, T653I, I656V, and T681C) secrete excessive amounts of cytokines, leading to a cytokine storm in response to viral infections, which causes neuropathology, seizures, coma, and even mortality (Shen et al. 2021).