Moreover, the human nucleoporins POM121 and importinβ mediate the nuclear import of a series of oncogenic transcription factors (e.g., such as the transcription factor E2F1 (E2F1), transcription factor p64 (c-Myc), and androgen receptor (AR), promoting the progression of prostate cancer (PCa) (Rodriguez-Bravo et al. 2018). Here, E2F1 is linked to Familial prostate cancer.