In addition to the aberrant expression of POM121, other studies have shown that the normal function of POM121 in the transport of TFEB (Wang et al. 2023c; Lin et al. 2024), which is vital for the autophagy-lysosome pathway (Brady et al. 2018), is impaired in C9orf72-ALS. Here, POM121 is linked to amyotrophic lateral sclerosis.