We are beginning to determine the contribution of the central and peripheral ADGRL1 to glucose sensing, development of obesity and type 2 diabetes.1,2 Interestingly, clinical features in a cohort of humans with pathogenic ADGRL1 variants show that four out of nine individuals with the variants were overweight.5 Similarly, Dietzsch et al.1 also identified variants of the human LPHN1 that contribute to the obesity phenotype. The gene discussed is ADGRL1; the disease is obesity disorder.