Significant attention has been directed towards the scn1lab gene in zebrafish, as it is the more conserved ortholog of the human SCN1A gene, and mutations in scn1lab have been consistently linked to epilepsy phenotypes in zebrafish, echoing the pathological features observed in Dravet syndrome (Griffin et al. 2017; Schoonheim et al. 2010; Sourbron et al. 2016; Weuring et al. 2020). This evidence concerns the gene SCN1A and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.