SKP2 and Sepsis: Among all the Skp2-binding proteins, SLC3A2 (also known as CD98hc or 4F2hc) (Supplemental Fig. 5A), a cell-surface transmembrane protein that functions upstream of ferroptosis [33], decreased after the onset of sepsis (Fig. 5B), suggesting that the decrease in SLC3A2 during sepsis may be mediated by Skp2.