In a previous study, we evaluated the early targets of MH and its modulatory properties on the proliferation, invasiveness, and angiogenic potential using two human breast cancer cell lines, the triple-negative MDA-MB-231 cells, and estrogen receptor-positive MCF-7 cells, and the non-neoplastic breast epithelial MCF-10A cell line. This evidence concerns the gene ESR1 and breast carcinoma.