In A53T brains, just as in our PFF model, we detected occasional colocalization between RhoA and pS129(+) (25.92% ± 7.7% [SD], n = 134), with higher colocalization rates observed in the E46K (49.25% ± 16.6% [SD], n = 64) and sporadic PD (67.35% ± 2.7% [SD], n = 221) brains (Figure 8J, left). Here, RHOA is linked to Parkinson disease.