The third is rs12153855 in the TNXB gene of the human leukocyte antigen (HLA) region, where the derived allele is associated with age-related macular degeneration and atopic dermatitis (Cipriani et al. 2012; Weidinger et al. 2013; Grange et al. 2015; Ye et al. 2016). Here, TNXB is linked to age-related macular degeneration.