Studies suggest a dichotomy between solTNF and tmTNF, in which multiple sclerosis is associated with the detrimental effects of solTNF via TNFR1, but tmTNF signaling via TNFR2 is important for repair and remyelination [17] Introduction of more selective anti-TNF agents or more efficient dose adjustment may hold the key to better outcomes [18, 19]. This evidence concerns the gene TNF and multiple sclerosis.