INS and Insulin resistance: Indeed, in visceral, but not subcutaneous, adipose tissue the expression of peroxisome proliferator-activated receptor gamma (PPAR-γ) was found to significantly increase, and that of interleukin (IL)-1b to significantly reduce after treatment with PRL [49], thereby suggesting that the correction of hypoprolactinemia might improve peripheral insulin sensitivity, fatty acid storage and glucose metabolism, and limit the impact of chronic inflammation characteristic of fat tissue [49], which reportedly contributes to the development of insulin resistance [53].