INS and metabolic syndrome: The resulting condition of hyperphagia triggers weight gain and increased BMI, and promotes several metabolic abnormalities including increased fat storage, atherogenic lipid profile (increased LDL-cholesterol and triglycerides, together with reduced HDL-cholesterol and apolipoproteins A-I and A-II), insulin and leptin resistance, and reduced adiponectin, thus leading to metabolic syndrome [2].