PRL and autoimmune disease: Following treatment with bromocriptine, PRL levels were < 5 ng/ml at either 28, 56 and 112 days of treatment in male mice, and between 10 and 15 ng/ml at the same time-points in female mice, thus suggesting that hypoprolactinemia severity might variably impact the incidence of autoimmune diseases, such as type 1 diabetes mellitus, in both sexes [50].