Correlation analyses revealed that RILPL2 expression demonstrated a significant positive correlation with CD4 + T cell infiltration in NSCLC (R = 0.294, P < 0.001), LUAD subgroup (R = 0.256, P = 0.038), and LUSC subgroup (R = 0.333, P = 0.004) respectively; RILPL2 expression exhibited a significant positive correlation with CD8 + T cell infiltration in NSCLC (R = 0.263, P = 0.002), LUAD subgroup (R = 0.280, P = 0.023), and LUSC subgroup (R = 0.250, P = 0.031) respectively (Tables 2, 3, 4, 5, Supplementary Tables 1, 2). This evidence concerns the gene RILPL2 and non-small cell lung carcinoma.