TEK and diabetes mellitus: The levels of a further three markers, soluble intercellular adhesion molecule-1 (sICAM-1), tyrosine protein kinase receptor 2 (Tie-2) and fms-related receptor tyrosine kinase 1 (Flt-1), were found to change towards the time of diabetes diagnosis, although the per-year effects for sICAM-1 and Tie-2 were not significant after FDR adjustment of p values (Fig. 3a).