These findings, along with our existing data illustrating the extensive regulatory effects of CC10 on the immunological activities, including differentiation, maturation, cytokine secretion, and endocytosis, of lung DCs in asthmatic mice as well as BMDCs in vitro, lead us to propose that CC10 inhibits allergen-induced Th2-type airway inflammatory responses in asthma primarily through modulating DC functions. This evidence concerns the gene SCGB1A1 and asthma.