RHOA and asthma: Given the critical role of IL-13 in orchestrating AHR in asthma, as demonstrated by Chiba et al. through the IL-13-mediated upregulation of RhoA protein via STAT6 activation [33], our findings suggest a potential mechanistic pathway wherein CC10 impedes IL-13 production or disrupts the IL-13/STAT6 signaling cascade, thereby attenuating AHR in asthma.