Conversely, the enhanced interaction of DNMT3AR882H with the PRC1 complex at H2AK119ub-modified target sites leads to the downregulation of differentiation-related genes (CEPBA, CEPBE, and PU.1) [10, 16, 63] .PRC1 regulates AML stem cells and leukemogenesis [132], which makes PRC1 an attractive target for new therapies. Here, PRC1 is linked to acute myeloid leukemia.