In contrast, aggressive transplantation leukemia is observed in Flt3ITD/wt, Tet2+/−, and Dnmt3a+/− mice within the same time scale, mainly associated with quantitative rather than qualitative differences in gene expression relative to Tet2mut/ Flt3mut or Dnmt3amut/ Flt3mut mice. Here, TET2 is linked to leukemia.