For example, in various pathologies, abnormal turnover has been observed for specific proteins such as amyloid-β (Aβ), Tau, or sTREM2 in Alzheimer disease (AD) (Mawuenyega et al. 2010, Suárez-Calvet et al. 2016, Sato et al. 2018), retinol-binding protein 4 (RBP4) in diabetes (Jourdan et al. 2009), or tissue remodeling during early-stage human heart failure (Lam et al. 2014). Here, RBP4 is linked to early-onset autosomal dominant Alzheimer disease.