This finding was in accordance with the results of a previous study in whichClostridiales was positively associated with tumor-infiltrating immune cells, such as CD3+ and CD8+ cells, in melanoma patients.6 Additionally, R. bromii is enriched in hepatocellular carcinoma (HCC) and non-small cell lung cancer (NSCLC)Akk+ patients who respond to immunotherapy. This evidence concerns the gene CD8A and hepatocellular carcinoma.