In experimental aspect, despite the availability of ApoE-/- andthe LDL receptor-deficient (LDLr-/-) mice, studies were conductedusing mice to investigate the effects of the potent proinflammatory cytokines,IL-1β, and IL-18 on atherosclerosis in the early 2000s [165, 166]. This evidence concerns the gene LDLR and atherosclerosis.