Due to the cross-talk between inflammation and lipidmetabolism that the NLRP3 inflammasome mediates, intensive studies have been beenspotlighted on the role of the NLRP3 inflammasome in atherogenesis in mousemodels, including its activation in ECs, immune cells (such as monocytes,macrophages and dendritic cells), and SMCs as well as its mechanism of action inatherosclerotic disease since then. This evidence concerns the gene NLRP3 and glycogen storage disease VI.