PTEN and Sepsis: Phosphataseand tensin homolog deleted on chromosome ten (PTEN), the target mRNA of miR-144,miR21, and miR-141, is downregulated in a hypoxic environment, which is reversedby bone marrow-derived MSC-Exos in a dose-dependent manner, and activates thedownstream PTEN/p-AKT and PTEN/β-catenin signaling pathways [33, 42, 43].In the mouse myocardial injury model induced by sepsis, a significant abundanceof miR-141 was found in bone marrow-derived MSC-Exo-treated mouse myocardialtissues.