CD40LG and Sepsis: Patients were divided into two groups:(1) the first group (Control Group) followed a standard care approach asrecommended by the Surviving Sepsis Campaign Guidelines; The second group (ActiveGroup) underwent extracorporeal blood purification therapy (EBPT) in combinationwith intravenous administration of IgM enriched immunoglobulin 5 mL/kg die for atleast three consecutive days, in conjunction with the standard approach (SSCGuidelines).