On the other hand, in the case ofhospitalization due to heart failure and cardiovascular disease, exercise had apositive effect on outcome in HF medication group I—none or ACE inhibitor/ARB,but in HF medication group II—beta blocker or diuretics, III—spironolactone,there was no significant correlation between exercise change and outcome(Supplementary Table 5). This evidence concerns the gene ACE and cardiovascular disorder.