After surgery, a significantincrease in circulating SEPP1 was observed in both sub-populations (p < 0.0001) but the two trends were statistically different (p = 0.001).Indeed, the rise in circulating SEPP1 manifested earlier in AKI patients (4 hSEPP1 546.5 [IQR 260.5–1000] vs. 52 [IQR 39–233.2] ng/mL, p = 0.0003;8 h SEPP1 1959 [IQR 1055.5–5303] vs. 628 [IQR 437.7–1254.5] ng/mL, p =0.003 in AKI vs. non-AKI, respectively). Here, SELENOP is linked to acute kidney injury.