With this approach, a 4.5folds increase in circulating SEPP1 from baseline to 4 h after CPB yield the bestdiagnostic capacity in diagnosing patients with following AKI with an AUC of0.843 (95% CI 0.683–1.000; p < 0.0001), a sensitivity of 75.0%(95% CI 42.8–94.5) and a specificity of 87.8% (95% CI 71.8–96.6). The gene discussed is SELENOP; the disease is acute kidney injury.