ACSL4 and cancer: Forexample, it was found that the expression of acyl-CoA synthetase long-chainfamily member 4 (ACSL4), which catalyzes the conversion of fatty acid to formacyl-CoA, correlates with cellular sensitivity to ferroptosis induction [114].For instance, when ACSL4 was suppressed by RNAi, cancer cells became moreresistant to ferroptosis [114].