Experiments have shownthat blunting autophagy in mice harboring an αB-crystallin mutationconsiderably expedited both the progression of heart failure and mortality [53].Finally, ER stress is considered a contributing factor to the pathogenesis ofdiabetic cardiomyopathy through induction of the endoplasmic reticulum stressresponse (ERSR) gene product, p53-upregulated modulator of apoptosis (PUMA) [54]. Here, BBC3 is linked to heart failure.