IL-10 knockout mice withisoprenaline-induced and TAC-induced CH can exacerbate cardiac maladaptiveremodelling, while IL-10 supplementation prevents or even reverses TAC-inducedcardiac remodelling by activating STAT3 and inhibiting NF-κB [96].Increased IL-10 production also modulates cardiac maladaptive remodelling due toα-galactosylceramide natural killer T cells activation and inhibition ofT cell immune activity with abatacept [97, 98]. The gene discussed is NFKB1; the disease is cyclic hematopoiesis.