After adjusting potential cofounders includingemergency presentation, AF patterns, subtypes of CAD, baseline hemoglobin, INR,HbA1c, NT-proBNP, LVEF, use of aspirin, Ticagrelor and use of coagulant therapy,CHA2DS2-VASc (HR 1.184, 95% CI 1.091–1.284, p < 0.001) andGRACE score at discharge (HR 1.009, 95% CI 1.004–1.014, p < 0.001)were independent predictors for subsequent MACCEs as continuous variables.Nevertheless, when treated as categorical variables, both CHA2DS2-VASc(low vs. intermediate: HR 1.449, 95% CI 0.935–2.244, p = 0.097; lowvs. The gene discussed is NPPB; the disease is atrial fibrillation.