Conversely, a remarkably reduced incidence of ischemic stroke, but not of MI,has been observed in 115 patients with FXI deficiency as compared to the generalpopulation, mirroring apparent protection against ischemic ictus cerebri due toreduced thrombin generation and augmented lysis of blood clots formed orembolized into cerebral arteries [69]. The gene discussed is F11; the disease is hyperinsulinemic hypoglycemia, familial, 4.