Previous research has shown that high-fat intake aggravatescardiac remodeling, including hypertrophy and interstitial fibrosis.Mitochondrial aldehyde dehydrogenase (ALDH2) serves an indispensable role inprotecting against cardiac anomalies from high-fat-induced obesity by enhancingautophagy [67]. Here, ALDH2 is linked to obesity due to melanocortin 4 receptor deficiency.