Calmodulin 1 (Calm1) mRNA, a member of the calcium/calmodulin-dependent protein kinase II (CamKII) signalingpathway, was not altered during m6A modification, whereas Calm1 proteinexpression was significantly reduced in failing heart tissue, suggesting that, inthe development of HF, m6A methylation affects calm1 translation, but nottranscription, during the development of HF. Here, CALM1 is linked to hydrops fetalis.