In a tacrolimus (TAC)-induced mousemodel of HF, Wang et al. [53] showed that high expression ofAMP-activated protein kinase α2 (AMPKα2) in cardiomyocytes mediated by recombinant adeno-associated virustype 9 could activate the phosphorylation of Serrate284 and Serrate495 (Ser284 and Ser495) sites on PINK1,thereby increasing the role of the PINK1/parkin signaling pathway inmitochondrial autophagy and alleviating HF. This evidence concerns the gene PINK1 and hydrops fetalis.