In patients withrecurrent pericarditis without a frank increase in inflammatory biomarkers (e.g.,CRP), low-dose glucocorticoids might be the treatment of choice sinceauto-inflammation is less likely to be the primary driver of the acute flare.However, additional signs (e.g., evidence of pericardial inflammation at CMR)should be considered before starting an IL-1 blocker. The gene discussed is CRP; the disease is pericarditis.