∙ Colchicine and the NLRP3 inh 16673-34-0 significantly reduced pericardial effusion at day 7 by 28% and 46%, respectively (p < 0.010 for both). NLRP3 inhibition with 16673-34-0 significantly reduced pericardial thickening by 32% (p = 0.003) Both colchicine and the selective NLRP3 inh reduced ASC aggregation (–93% and –78% vs. vehicle-treated mice, respectively, p < 0.001). Here, NLRP3 is linked to pericardial effusion.