For incident heart failure, Yan and colleagues [65] published largestudy from a general population that showed hs-cTnI levels were independentlyassociated with incident heart failure and different hs-cTnI cutoff values of 2.6ng/L for females and 4.2 ng/L for males were derived to optimally identifyindividuals at risk. Here, TNNI3 is linked to heart failure.