Coronary microvasculardysfunction was present in 75% of patients with HFpEF and related to theseverity of HF (as measured by N-Terminal prohormone of B-type natriuretic peptide [NT-proBNP]) and cardiac dysfunction (ventricular/atrial strain) aswell as markers of systemic endothelial dysfunction [38]. This evidence concerns the gene NPPB and hydrops fetalis.