Given the critically discussed pathophysiological and cellularfunctions and the important clinical significance of GDF-15 as a biomarker inCVD, we have summarized here the basic research findings on different cell types.In the context of cellular stress and inflammation, we further elucidated thesignaling pathway of GDF-15 in coronary artery disease (CAD), the most common CVDin developing and industrial nations. Here, GDF15 is linked to coronary artery disorder.