CCR2 is a key chemokine receptor for monocyte recruitment at earlystage of atherosclerosis and is decreased by GDF-15–deficient macrophages [75].The direct interaction of GDF-15 with the chemokine receptor CCR2 functionsuggests that the GDF-15-induced macrophage mobility modulates the CCR2 response[75]. The gene discussed is GDF15; the disease is atherosclerosis.