AFP and nongerminomatous germ cell tumor: In non germinomatous germ cell tumour (NGGCT), the European SIOP-CNS-GCT-96 trial, evaluated a strategy consisting of four courses of PEI (cisplatin-etoposide- ifosfamide), followed by 54 Gy focal radiotherapy in non-metastatic NGGCT (or 30 Gy craniospinal if metastatic) and identified a high-risk (HR) group of patients, namely those aged less than six years or with Alpha-fetoprotein (AFP) level in serum and/or cerebrospinal fluid (CSF) above 1000 ng/ml at diagnosis (7).