GPT and Gastrointestinal hemorrhage: The CTCAE grade 3 or 4 adverse events observed were an increased alanine aminotransferase/aspartate aminotransferase levels (n = 2, 5%), thrombocytopenia (n = 4, 11%), and leukopenia (n = 2, 5%); As to adverse events related to TKIs, the most common adverse event was hand-foot reaction (16 patients, 43%), of which 6 (11%) had grade 3 adverse events; Four (11%) presented with upper gastrointestinal bleeding and corresponding black stool symptoms, and one patient presented with death due to acute upper gastrointestinal bleeding.