For instance, a number of studies have depicted that 17-β-estradiol or E2, a natural female steroid hormone, resulted in increased cell proliferation, growth, viability, and migration of various OVC cells and caused an increase in tumor growth and size in vivo through ER signaling pathway (7, 76, 89–93, 95, 97, 98, 102, 104, 108, 111). Here, ESR1 is linked to neoplasm.